The cost is certainly affected, but does the built in watercooling on the Sapphire Toxic X1900 XTX make it worth your money?  Drop by ExtremeTech to see if the overclocking potential makes it a contender against nVIDIA’s newest.
“Water-cooled CPUs and GPUs are generally a pain to set up, though. There are tubes to cut and clamp, reservoirs to fill, pumps to install, not to mention that it likely voids your warranty. For those who want to push a high-end graphics card to the limit, Sapphire has an elegant solution in it’s Toxic X1900 XTX. The company offers a factory-sealed, ready-to-roll water-cooled graphics card that’s as easy to set up as any standard air-cooled card. Does the performance jump justify the extra price?”

Here are some more Graphics Card articles from around the web:

Click Here to go to Video Cards   Graphics Cards