There are a variety of devices out there meant to improve the mouse by allowing your hand to sit in a more natural position while you are using your computer. From trackballs to joystick-like devices with a sensor on the bottom, they have seen only limited acceptance but perhaps the HE Mouse might gain more fans as it does very much resemble a mouse flipped on its side.  That allows a familiar look while still putting your wrist in a much more natural position and comes in both wired and wireless versions.  You still get gaming features such as settings between 800 and 3400 dpi and a total of 5 buttons so gaming will not be a problem.  Check out Hardware.Info if you think your wrists could use a break.

"We reviewed the HE Mouse. Ergonomic input devices are rare these days, so it was great to test a product that tried something different. The vertical orientation of the HE Mouse does indeed reduce the strain on your hand, wrist and forearm, so if you’re susceptible to RSI then this could be a good alternative. It falls short of perfection, however, since the lack of an accurate sensor limits the applications for this mouse."

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