The first software to enable a GPU to be used for general purposes will come from nVIDIA, and be released in June according to this story on The Inquirer.  It has been in beta for a little while, but this will be an official release.  As well, nVIDIA mentioned their new series of GPGPUs will be the 9800, and will feature double-precision floating point arithmetic, a must in scientific calculations, and handy for the gamer too.
“MASSAGING a room full of industry analysts yesterday, Nvidia spinners and spinnerettes announced that the first release of its CUDA GPGPU software will hit in June. Whilst alphas and betas have been flying around for some time, the 1.0 release is going to come some time in the next few weeks.”

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